Short Description:
CAS number: 27164-46-1
Molecular formula: C14H15N8NaO4S3
molecular weight: 478.5
Chemical structure：
| Basic Information | |
| Product name | Cefazolin sodium salt |
| CAS No. | 27164-46-1 |
| Appearance | White to Off-White crystalline powder |
| Grade | Pharma Grade |
| Storage | Keep in dark place,Inert atmosphere,2-8°C |
| Shelf Life | 2 years |
| Stability | Stable, but may be heat sensitive - store in cool conditions. May discolour upon exposure to light - store in the dark. Incompatible with strong oxidizing agents. |
| Package | 25kg/Drum |
Product Description
A semi synthetic antibiotic containing cephalosporins in the molecule of cephalosporins. Translated as Xianfeng mycin. belong to β－ Lactam antibiotics, yes β- The derivatives of 7-aminocephalosporanic acid (7-ACA) in lactam antibiotics have similar bactericidal mechanisms. This type of medicine can destroy the cell wall of bacteria and kill them during the reproductive period. It has a strong selective effect on bacteria and almost no toxicity to humans, with advantages such as wide antibacterial spectrum, strong antibacterial effect, resistance to penicillin enzymes, and less allergic reactions compared to penicillin. So it is an important antibiotic with high efficiency, low toxicity, and wide clinical application. The first generation cephalosporins were developed earlier, with stronger antibacterial activity compared to Chemicalbook, narrower antibacterial spectrum, and better anti Gram positive bacteria effects than Gram negative bacteria. Produced by Staphylococcus aureus β- Lactamase is stable and can inhibit the production of negative bacteria β- Lactamases are unstable and can still be produced by many Gram negative bacteria β- Damaged by lactamases. Cefazolin sodium is a semi synthetic first generation cephalosporin that has antibacterial effects against both gram-positive and gram-negative bacteria. It is commonly used in infections of the respiratory system, urogenital system, skin soft tissue, bone and joint, and biliary tract caused by sensitive bacteria, as well as in endocarditis, sepsis, pharyngeal and ear infections. It has strong activity against gram-positive bacteria such as Staphylococcus aureus and Streptococcus (excluding Enterococcus), and is superior to the second Third generation cephalosporins.
Chemical Use
Cefazolin (Ancef, Kefzol) is one of a series of semisyntheticcephalosporins in which the C-3 acetoxy function has beenreplaced by a thiol-containing heterocycle—here, 5-methyl-2-thio-1,3,4-thiadiazole. It also contains the somewhatunusual tetrazolylacetyl acylating group. Cefazolin wasreleased in 1973 as a water-soluble sodium salt. It is activeonly by parenteral administration.
Cefazolin provides higher serum levels, slower renalclearance, and a longer half-life than other first-generationcephalosporins. It is approximately 75% protein bound inplasma, a higher value than for most other cephalosporins.Early in vitro and clinical studies suggest that cefazolin ismore active against Gram-negative bacilli but less activeagainst Gram-positive cocci than either cephalothin orcephaloridine. Occurrence rates of thrombophlebitis followingintravenous injection and pain at the site of intramuscularinjection appear to be the lowest of the parenteralcephalosporins.
