Cefuroxime Axetil(CAS NO.55268-75-2 )

Cefuroxime axetil is a second-generation cephalosporin antibiotic. After oral absorption through the gastrointestinal tract, it rapidly hydrolyzes into cefuroxime under the action of esterase and exerts antibacterial effects. The activity against Gram positive cocci is similar or slightly inferior to that of first generation cephalosporins, but it appears quite stable against β - lactases produced by Staphylococcus and Gram negative bacilli. Except for methicillin-resistant Staphylococcus, Enterococcus, and Listeria, all other positive cocci (including anaerobic cocci) are sensitive to this product. The antibacterial activity of this product against Staphylococcus aureus is inferior to that of cefazolin. 1-2mg/L of this product can inhibit both penicillin sensitive and resistant Staphylococcus aureus. Has strong antibacterial activity against Haemophilus influenzae, and is sensitive to Escherichia coli, Proteus mirabilis, and other bacteria; Indole positive Proteobacter, Citrobacter, and Acinetobacter have poor sensitivity to this product, while most Serratia are resistant. Pseudomonas aeruginosa, Campylobacter, and Bacteroidetes fragilis are resistant to this product. The mechanism of action of this product is to inhibit the synthesis of bacterial cell walls.