| Basic Information | |
| Product name | Amantadine Hydrochloride |
| Grade | Pharma Grade |
| Appearance | White crystalline powder |
| Analysis standard | USP |
| Assay | 98.5%-100.5% |
| Shelf life | 3 years |
| Packing | 25kg/drum |
| Characteristic | Stable, May be weakly light or air sensitive. Incompatible with oxidizing agents, alkalies, iron, copper |
| Condition | Store at +5°C to +30°C |
Description
It is absorbed rapidly and completely in gastrointestinal tract and distributed in saliva and nasal secretion. The content in animal tissues, especially in the lungs, was higher than that in serum. This product can pass through placenta and blood-brain barrier. The half-life of normal renal function is 11~15 hours, and that of renal failure is 24 hours. Long-term dialysis patients can reach 7~10 days.
Function
Amantadine hydrochloride is a symmetrical tricyclic amine, which can inhibit the virus from penetrating into the host cell, and affect the virus's dehulling, inhibit its reproduction, and play a role in the treatment and prevention of viral infection.
Application
- Parkinson's Disease: Amantadine HCl is primarily used in the treatment of Parkinson's disease, a neurodegenerative disorder characterized by muscle rigidity, tremors, and impaired balance. It helps to improve motor function and reduce symptoms by modulating dopamine levels and NMDA receptor activity.
- Influenza A Virus Prophylaxis: Additionally, amantadine HCl is indicated for the prophylaxis of influenza A virus infections. By inhibiting the viral M2 ion channel, it prevents the virus from uncoating and replicating within host cells.
- Post-Stroke Syndrome: In some cases, amantadine HCl may also be used to treat post-stroke syndrome, particularly when it involves hemiparesis (weakness on one side of the body), to improve motor function and mobility.
