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Neomycin Sulfate

Short Description:

CAS number:1405-10-3

Molecular formula: C23H48N6O17S

Molecular weight:712.72

Chemical structure:


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  • Product Detail

    Product Tags

    Basic Information
    Product name Neomycin Sulfate
    CAS No. 1405-10-3
    Appearance White to Slightly Yellow Powder
    Grade Pharma Grade
    Water Solubility Soluble in water
    Storage 2-8°C
    Shelf Life 2 Years
    Package 25kg/Drum

    Product Description

    Neomycin sulfate is an aminoglycoside antibiotic and calcium channel protein inhibitor. Neomycin sulfate also binds to prokaryotic ribosomes inhibiting translation and is effective against gram-positive and gram-negative bacteria. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNase I induced DNA degradation. It is used to prevent or treat skin infections caused by bacteria. It is not effective against fungal or viral infections.

    Application

    Neomycin sulfate is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.


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